Rare disease modeling

We describe the modeling of a rare inherited neurodegenerative disease X-linked Dystonia Parkinsonism and show oligodendrocyte dysfunction and widespread myelin disruption to be a key feature of disease pathology.

Glial lipids in neurodegeneration

Lipidomics and metabolomics analyses to identify disease-specific states of astrocytes and microglia in Alzheimer's disease and neuroinflammation.

Molecular profiling of reactive astrocyte subtypes

Characterizing the protein profiles of reactive astrocyte subtypes including interferon-responsive reactive astrocytes and neurotoxic reactive astrocytes.

Tool development to investigate glial function

Development of biochemical tools to evaluate how glia respond to the pathogenic Aβ peptide associated with Alzheimer's disease.