PRIYA PRAKASH - Neurotoxic reactive astrocytes induce cell death via

Journal article

Kevin A. Guttenplan, Maya K. Weigel*, Priya Prakash*, Prageeth R. Wijewardhane, Philip Hasel, Uriel A Rufen-Blanchette, Alexandra E. Münch, Jacob A. Blum, Jonathan A Fine, Mikaela C. Neal, Kimberly Bruce, Aaron Gitler, Gaurav Chopra, Shane A. Liddelow, Ben Barres
Nature, 2021

Semantic Scholar DOI PubMed

Cite

APA Click to copy
Guttenplan, K. A., Weigel*, M. K., Prakash*, P., Wijewardhane, P. R., Hasel, P., Rufen-Blanchette, U. A., … Barres, B. (2021). Neurotoxic reactive astrocytes induce cell death via saturated lipids. Nature.

Chicago/Turabian Click to copy
Guttenplan, Kevin A., Maya K. Weigel*, Priya Prakash*, Prageeth R. Wijewardhane, Philip Hasel, Uriel A Rufen-Blanchette, Alexandra E. Münch, et al. “Neurotoxic Reactive Astrocytes Induce Cell Death via Saturated Lipids.” Nature (2021).

MLA Click to copy
Guttenplan, Kevin A., et al. “Neurotoxic Reactive Astrocytes Induce Cell Death via Saturated Lipids.” Nature, 2021.

BibTeX Click to copy

@article{kevin2021a,
  title = {Neurotoxic reactive astrocytes induce cell death via saturated lipids},
  year = {2021},
  journal = {Nature},
  author = {Guttenplan, Kevin A. and Weigel*, Maya K. and Prakash*, Priya and Wijewardhane, Prageeth R. and Hasel, Philip and Rufen-Blanchette, Uriel A and Münch, Alexandra E. and Blum, Jacob A. and Fine, Jonathan A and Neal, Mikaela C. and Bruce, Kimberly and Gitler, Aaron and Chopra, Gaurav and Liddelow, Shane A. and Barres, Ben}
}

Abstract

Astrocytes regulate the response of the central nervous system to disease and injury and have been hypothesized to actively kill neurons in neurodegenerative disease. Here we report an approach to isolate one component of the long-sought astrocyte-derived toxic factor. Notably, instead of a protein, saturated lipids contained in APOE and APOJ lipoparticles mediate astrocyte-induced toxicity. Eliminating the formation of long-chain saturated lipids by astrocyte-specific knockout of the saturated lipid synthesis enzyme ELOVL1 mitigates astrocyte-mediated toxicity in vitro as well as in a model of acute axonal injury in vivo. These results suggest a mechanism by which astrocytes kill cells in the central nervous system.